Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder

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dc.creatorPaulo Marcosbrasil Rocha
dc.creatorSimone Becho de Campos
dc.creatorFernando Silva Neves
dc.creatorHumberto Corrêa da Silva Filho
dc.date.accessioned2023-07-12T21:15:26Z
dc.date.accessioned2025-09-08T23:01:12Z
dc.date.available2023-07-12T21:15:26Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.4306/pi.2017.14.5.674
dc.identifier.issn17383684
dc.identifier.urihttps://hdl.handle.net/1843/56148
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Psychiatry Investigation
dc.rightsAcesso Aberto
dc.subjectTranstorno Bipolar
dc.subjectProteínas Circadianas Period
dc.subjectRelógios Circadianos
dc.subjectPeriodicidade
dc.subject.otherBipolar disorder
dc.subject.otherPERIOD3
dc.subject.otherGene
dc.subject.otherCircadian
dc.subject.otherBiological rhythms
dc.titleGenetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder
dc.typeArtigo de periódico
local.citation.epage680
local.citation.issue5
local.citation.spage674
local.citation.volume14
local.description.resumoObjectiveaaCircadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.Methods This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we asessed genetic association of the Per3 gene with sleep quality in the BD group. ResultsaaThere were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ 2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD.
local.identifier.orcidhttps://orcid.org/0000-0003-2757-1375
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.5.674

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