Alpha-Actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game

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dc.creatorDaniel Barbosa Coelho
dc.creatorEduardo Mendonça Pimenta
dc.creatorIzinara Cruz Rosse
dc.creatorChristiano Veneroso
dc.creatorGuilherme de Azambuja Pussieldi
dc.creatorLenice Kappes Becker
dc.creatorEmerson Cruz de Oiveira
dc.creatorMaria Raquel Santos Carvalho
dc.creatorEmerson Silami Garcia
dc.date.accessioned2023-02-24T14:10:57Z
dc.date.accessioned2025-09-09T00:18:30Z
dc.date.available2023-02-24T14:10:57Z
dc.date.issued2019-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1519/JSC.0000000000002575
dc.identifier.issn1533-4287
dc.identifier.urihttps://hdl.handle.net/1843/50361
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Strength and Conditioning Research
dc.rightsAcesso Restrito
dc.subjectGenética - Expressão
dc.subjectEstresse fisiológico
dc.subjectAvaliação de desempenho
dc.subjectProteína de ligação
dc.subjectFerimentos e lesões
dc.subjectMarcadores biológicos / sangue
dc.subject.otherACTN3
dc.subject.otherPhysiological stress
dc.subject.otherPerformance
dc.subject.otherAlpha-actin
dc.subject.otherMuscle microtrauma
dc.subject.otherBlood markers
dc.titleAlpha-Actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game
dc.typeArtigo de periódico
local.citation.epage2664
local.citation.issue10
local.citation.spage2655
local.citation.volume33
local.description.resumoCoelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res 33(10): 2655–2664, 2019—The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/RX (p < 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/RX group (p < 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p < 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athlete.
local.identifier.orcidhttps://orcid.org/0000-0003-0346-492X
local.identifier.orcidhttp://orcid.org/0000-0001-8968-0089
local.identifier.orcidhttps://orcid.org/0000-0003-2058-689X
local.identifier.orcidhttps://orcid.org/0000-0002-8291-3270
local.identifier.orcidhttps://orcid.org/0000-0002-0275-5226
local.identifier.orcidhttp://orcid.org/0000-0002-9462-5719
local.identifier.orcidhttp://orcid.org/0000-0002-8982-4705
local.identifier.orcidhttp://orcid.org/0000-0002-1744-448X
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/nsca-jscr/Fulltext/2019/10000/Alpha_Actinin_3_R577X_Polymorphism_Influences.10.aspx

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