Inflammatory biomarkers in children with cerebral palsy: A systematic review

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dc.creatorRafael Coelho Magalhaes
dc.creatorJanaina Matos Moreira
dc.creatorAmanda Oliveira Lauar
dc.creatorAriadna Andrade Saldanha da Silva
dc.creatorAntônio Lúcio Teixeira Júnior
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2022-06-13T17:43:35Z
dc.date.accessioned2025-09-09T01:01:51Z
dc.date.available2022-06-13T17:43:35Z
dc.date.issued2019-12
dc.identifier.doihttps://doi.org/10.1016/j.ridd.2019.103508
dc.identifier.issn0891-4222
dc.identifier.urihttps://hdl.handle.net/1843/42474
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofResearch in Developmental Disabilities
dc.rightsAcesso Restrito
dc.subjectParalisia cerebral
dc.subjectInflamação
dc.subjectEstresse oxidativo
dc.subjectCitocinas
dc.subjectSistema nervoso central / lesões
dc.subject.otherCerebral palsy
dc.subject.otherInflammation
dc.subject.otherOxidative stress
dc.subject.otherCytokines
dc.subject.otherNeurodevelopment outcome
dc.titleInflammatory biomarkers in children with cerebral palsy: A systematic review
dc.typeArtigo de periódico
local.citation.epage13
local.citation.spage1
local.citation.volume95
local.description.resumoBackground: An exacerbated systemic inflammatory response has been associated with the occurrence of central nervous system injuries that may determine, in long term, motor, sensorial and cognitive disabilities. Persistence of this exacerbated inflammatory response seems to be involved in the pathophysiology of cerebral palsy (CP). Methods: A systematic search was conducted in Bireme, Embase, PubMed and Scopus including studies that were published until August 2019. The key words used were “cerebral palsy”, “brain injury”, “inflammation”, “oxidative stress”, “cytokines”, “chemokines”, “neuropsychomotor development”, “neurodevelopment outcomes” and “child”. The quality of the eligible studies was determined according to the criteria suggested by the Newcastle-Ottawa Scale (NOS). Results: Fourteen eligible studies aimed to investigate the association between peripheral inflammatory molecules and neurodevelopment in infants. The studies differed regarding CP-related risk factors and its classification. Inflammatory proteins were measured in blood, plasma, serum, cerebrospinal fluid or urine. In ten studies, higher circulating levels of cytokines, including IL-1β, IL-6, TNF and CXCL8/IL-8, were associated with abnormal neurological findings. Conclusion: The investigation of the potential association between inflammatory molecules and neurological development in children with CP requires further original studies in order to clarify the influence of prenatal and perinatal inflammation on neurological outcomes.
local.identifier.orcidhttp://orcid.org/0000-0002-8960-2256
local.identifier.orcidhttps://orcid.org/0000-0001-5369-9175
local.identifier.orcidhttps://orcid.org/ 0000-0002-9621-5422
local.identifier.orcidhttps://orcid.org/ 0000-0001-9222-3882
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0891422219301751?via%3Dihub

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