Chronic alcohol administration alters metabolomic profile of murine bone marrow

Página do item simplificado
dc.creatorTássia Tatiane Pontes Pereira
dc.creatorErnani Pinto
dc.creatorRicardo Santiago Gomez
dc.creatorMauro Martins Teixeira
dc.creatorAdriana Nori de Macedo
dc.creatorGisele André Baptista Canuto
dc.creatorFrederico Marianetti Soriani
dc.creatorFilipe Fideles Duarte-andrade
dc.creatorJéssica Gardone Vitório
dc.creatorTaiane do Espírito Santo Pereira
dc.creatorFlavia Rayssa Braga Martins
dc.creatorJéssica Amanda Marques Souza
dc.creatorNathália Luisa Malacco
dc.creatorEliza Mathias Melo
dc.creatorCarolina Raíssa Costa Picossi
dc.date.accessioned2025-01-21T20:51:10Z
dc.date.accessioned2025-09-09T00:14:04Z
dc.date.available2025-01-21T20:51:10Z
dc.date.issued2023-04-05
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2023.1128352
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/1843/79381
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectAlcoolismo
dc.subjectÁlcool no organismo
dc.subjectMetabólitos
dc.subjectSistema imunológico
dc.subjectCélulas da medula óssea
dc.subject.otherAlcoholism
dc.subject.otherBone marrow
dc.subject.otherMetabolome
dc.subject.otherCell function
dc.subject.otherMetabolites
dc.subject.otherImmune system
dc.titleChronic alcohol administration alters metabolomic profile of murine bone marrow
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume14
local.description.resumoIntroduction: People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response. Methods: We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography–coupled mass spectrometry (GC–MS). Results: We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanoltreated animals: uracil, succinate, proline, nicotinamide, and tyrosine. Discussion: Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system.
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1128352/full

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Chronic alcohol administration alters metabolomic profile of murine bone marrow.pdf
Tamanho:
722.76 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG