Radiation - induced oral mucositis in brazilian patients: prevalence and associated factors

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dc.creatorIgor Figueiredo Pereira
dc.creatorRamon Targino Firmino
dc.creatorHenrique Côrtes Meira
dc.creatorBelmiro Cavalcanti do Egito Vasconcelos
dc.creatorVladimir Reimar Augusto de Souza Noronha
dc.creatorVagner Rodrigues Santos
dc.date.accessioned2025-07-30T17:58:22Z
dc.date.accessioned2025-09-08T23:19:36Z
dc.date.available2025-07-30T17:58:22Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doihttps://iv.iiarjournals.org/content/33/2/605.long#:~:text=https%3A//doi.org/10.21873/invivo.11517
dc.identifier.issn1791-7549
dc.identifier.urihttps://hdl.handle.net/1843/83929
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofIn Vivo
dc.rightsAcesso Restrito
dc.subjectRadiotherapy
dc.subjectDrug therapy
dc.subjectEpidemiology
dc.subjectHead and neck neoplasms
dc.subjectStomatitis
dc.subjectPrevalence
dc.subjectCandidiasis, oral
dc.subjectOsteoradionecrosis
dc.subjectAssociation
dc.subject.otherRadiotherapy
dc.subject.otherChemotherapy
dc.subject.otherEpidemiology
dc.subject.otherHead and neck cancer
dc.subject.otherOral mucositis
dc.titleRadiation - induced oral mucositis in brazilian patients: prevalence and associated factors
dc.typeArtigo de periódico
local.citation.epage609
local.citation.issue2
local.citation.spage605
local.citation.volume33
local.description.resumoAim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. Patients and methods: A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. Results: Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). Conclusion: Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.
local.identifier.orcidhttps://orcid.org/0000-0003-1805-4683
local.identifier.orcidhttps://orcid.org/0000-0001-5581-0658
local.identifier.orcidhttps://orcid.org/0000-0002-0747-8950
local.identifier.orcidhttps://orcid.org/0000-0002-6515-1489
local.identifier.orcidhttps://orcid.org/0000-0002-2809-0859
local.identifier.orcidhttps://orcid.org/0000-0002-5370-4867
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://iv.iiarjournals.org/content/33/2/605.long

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