Odontogenic myxomas lack PDGFRB mutations reported in myofibromas

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dc.creatorElisa Carvalho de Siqueira
dc.creatorSilvia Ferreira de Sousa
dc.creatorRoman Carlos
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMario José Romañach Gonzalez Sobrinho
dc.creatorRicardo Santiago Gomez
dc.creatorCarolina Cavalieri Gomes
dc.date.accessioned2025-08-28T20:03:25Z
dc.date.accessioned2025-09-08T23:53:39Z
dc.date.available2025-08-28T20:03:25Z
dc.date.issued2020-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.13004
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/84696
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectMyofibroma
dc.subjectNeoplasms
dc.subjectGenetics
dc.subjectOdontogenic tumors
dc.subjectGenes
dc.subjectMutation
dc.subjectMyxoma
dc.subject.otherPDGFRB
dc.subject.otherBenign tumors
dc.subject.otherGenetics
dc.subject.otherMyofibroblastic tumor
dc.subject.otherMyofibroma
dc.subject.otherOdontogenic tumors
dc.titleOdontogenic myxomas lack PDGFRB mutations reported in myofibromas
dc.typeArtigo de periódico
local.citation.epage283
local.citation.issue3
local.citation.spage278
local.citation.volume49
local.description.resumoBackground: The molecular pathogenesis of odontogenic myxoma has not been established yet. Considering that odontogenic myxoma may show myofibroblastic differentiation and myxoid areas can be observed in intra-osseous myofibromas, we tested the hypothesis whether both tumors share a common molecular profile. As recent studies have reported PDGFRB recurrent driver mutations in myofibroma, we evaluated PDGFRB mutations in odontogenic myxomas. Methods: A convenience sample of 15 odontogenic myxomas cases was selected. We direct sequenced PDGFRB exons 12 and 14, where p.R561C (c.1681C>T) and p.N666K (c.1998C>G) hotspot mutations have been reported among others in single and/or multiple myofibromas. Results: All 15 odontogenic myxoma samples were successfully sequenced, and all 15 had wild-type sequences for the PDGFRB mutations investigated. Conclusion: Our findings suggest that PDGFRB mutations do not play a role in odontogenic myxoma pathogenesis, which might be helpful in the differential diagnosis of challenging cases.
local.identifier.orcidhttps://orcid.org/0000-0002-3005-1736
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-1022-8087
local.identifier.orcidhttps://orcid.org/0000-0002-3259-606X
local.identifier.orcidhttps://orcid.org/0000-0002-7853-5916
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13004

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