Adjunctive effects of photodynamic therapy using indocyanine green in residual pockets during periodontal maintenance therapy: a split-mouth randomized controlled trial

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dc.creatorFernando Oliveira Costa
dc.creatorLuís Otávio Miranda Cota
dc.creatorRafael Paschoal Esteves Lima
dc.creatorAdriana Moreira Costa
dc.creatorAmanda Almeida Costa
dc.creatorGustavo Henrique Mattos Pereira
dc.creatorSheila Cavalca Cortelli
dc.creatorJosé Roberto Cortelli
dc.creatorRenata Magalhães Cyrino
dc.creatorTarcília Aparecida Silva
dc.date.accessioned2024-09-26T22:39:38Z
dc.date.accessioned2025-09-09T00:55:49Z
dc.date.available2024-09-26T22:39:38Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/jper.22-0672
dc.identifier.issn1943-3670
dc.identifier.urihttps://hdl.handle.net/1843/76946
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Periodontology
dc.rightsAcesso Restrito
dc.subjectIndocyanine green
dc.subjectMaintenance
dc.subjectMicrobiology
dc.subjectPeriodontal pocket
dc.subjectPhotochemotherapy
dc.subjectBacteria
dc.subjectHemorrhage
dc.subjectPeriodontics
dc.subject.otherIndocyanine green
dc.subject.otherMaintenance
dc.subject.otherMicrobiology
dc.subject.otherPeriodontal pocket
dc.subject.otherPhotodynamic therapy.
dc.titleAdjunctive effects of photodynamic therapy using indocyanine green in residual pockets during periodontal maintenance therapy: a split-mouth randomized controlled trial
dc.typeArtigo de periódico
local.citation.epage1111
local.citation.issue9
local.citation.spage1100
local.citation.volume94
local.description.resumoBackground: Prospective studies have reported conflicting results regarding the adjunctive effect of antimicrobial photodynamic therapy (aPDT) on clinical and microbiological parameters in individuals under periodontal maintenance therapy (PMT). This study aimed to evaluate the clinical and microbiological adjunctive effects of aPDT using indocyanine green (ICG) in residual sites with probing depth (PD) ≥5 mm during PMT in comparison with scaling and root planing (SRP) alone. Methods: A split-mouth randomized controlled clinical trial was conducted with 24 individuals in a PMT program. Contralateral quadrants with eligible residual sites were randomly assigned to either SRP + aPDT (test group) or SRP alone (control). aPDT included ICG dye and diode laser (909 nm) performed together with SRP and repeated 15 days after. Periodontal clinical parameters, periodontal inflamed surface area (PISA) index, and subgingival biofilm samples were collected at baseline (T1), 3 (T2), and 6 months later (T3). Microbiological analyses were performed by quantitative real-time polymerase chain reaction. Results: Significant improvements were observed in all clinical and microbiological parameters in both groups from T1 to T3. However, no significant differences were observed regarding plaque index, PD, and clinical attachment level. Test group showed significantly greater reductions in bleeding on probing (BOP), PISA index, and Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans levels, when compared with controls. Conclusions: Both treatments resulted in significant clinical periodontal improvements, but with no significant differences between groups except from inflammation parameters. aPDT using ICG resulted in significant reductions in BOP and PISA index, as well as in P. gingivalis and A. actinomycetemcomitans levels.
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.identifier.orcidhttps://orcid.org/0000-0003-1517-584
local.identifier.orcidhttps://orcid.org/0000-0003-4343-3845
local.identifier.orcidhttps://orcid.org/0000-0001-7655-8666
local.identifier.orcidhttps://orcid.org/0000-0001-9787-3323
local.identifier.orcidhttps://orcid.org/0000-0003-0176-0741
local.identifier.orcidhttps://orcid.org/0000-0001-5147-0705
local.identifier.orcidhttps://orcid.org/0000-0003-0809-6935
local.identifier.orcidhttps://orcid.org/0000-0002-2090-2752
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://aap.onlinelibrary.wiley.com/doi/10.1002/JPER.22-0672

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