Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia

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dc.creatorElenapérez'nadales
dc.creatorRanganathan n. Iyer
dc.creatorz. Koçak Tufan
dc.creatore. Kazak
dc.creatorm. David
dc.creatore. Lease
dc.creatorn. Nestorova
dc.creatorg. Cornaglia
dc.creatorm. Akova
dc.creatorSeema Metha
dc.creatorElisa Grazia Calvi
dc.creatorE.m. Seminari
dc.creatorMaristela Pinheiro Freire
dc.creatorj. Carratalá
dc.creatora. Domínguez
dc.creatore. Cordero
dc.creatorJ.a. Lepe
dc.creatorm. Montejo
dc.creatore. Merino de Lucas
dc.creatorB.m. Eriksson
dc.creatorc. Van Delden
dc.creatoro. Manuel
dc.creatorh. Arslan
dc.creatorMario Tumbarello
dc.creatorMarco Falcone
dc.creatorMario Fernández'ruiz
dc.creatorJosé María Costa'mateo
dc.creatorMeenakshi m. Rana
dc.creatorTania Mara Varejão Strabelli
dc.creatorMical Paul
dc.creatorBelén Gutiérrez'gutiérrez
dc.creatorMaría Carmen Fariñas
dc.creatorWanessa Trindade Clemente
dc.creatorEmmanuel Roilides
dc.creatorPatricia Muñoz García
dc.creatorLaurent Dewispelaere
dc.creatorBelén Loeches
dc.creatorWarren Lowman
dc.creatorBan Hock Tan
dc.creatorRosa Escudero'sánchez
dc.creatorMarta Bodro Marimont
dc.creatorAlejandra m. Natera
dc.creatorPaolo Antonio Grossi
dc.creatorFabio Soldani
dc.creatorFiliz Gunseren
dc.creatorNina Nestorova
dc.creatorÁlvaro Pascual
dc.creatorLuis Martínez'martínez
dc.creatorJosé María Aguado
dc.creatorJesús Rodríguez'baño
dc.creatorJulián Torre'cisneros
dc.creatorA.t. Wan Song
dc.creatorEdson Abdala
dc.creatorw. Andraus
dc.creatorL.a. Carneiro D'albuquerque
dc.creatore. David'neto
dc.creatorf. Jota de Paula
dc.creatorf. Rossi
dc.creatord. Ostrander
dc.creatorr. Avery
dc.creatorm. Rizzi
dc.creatorA.r. Losito
dc.creatorf. Raffaelli
dc.creatorMaira Reina Magalhães
dc.creatorp. Del Giacomo
dc.creatorg. Tiseo
dc.creatorj. Lora'tamayo
dc.creatorr San'juan
dc.creatori. Gracia'ahufinger
dc.creatorj. Castón
dc.creatorY.a. Ruiz
dc.creatorD.r. Altman
dc.creatorS.v. Campos
dc.creatorn. Bar'sinai
dc.creatorAlessandra Mularoni
dc.creatorf. Koppel
dc.creatorf. Arnaiz de Las Revillas Almajano
dc.creatorc. González Rico
dc.creatorm. Fernández Martínez
dc.creatorP.h.o. Mourão
dc.creatorF.a. Neves
dc.creatorJanita Ferreira
dc.creatora. Pyrpasopoulou
dc.creatore. Iosifidis
dc.creatori. Romiopoulos
dc.creatorFrancesco Monaco
dc.creatorM.v. Minero
dc.creatorc Sánchez'carrillo
dc.creators. Lardo
dc.creatorj. Coussement
dc.creatorm. Dodémont
dc.creatork. Jiayun
dc.creatorp. Martín'dávila
dc.creatorj. Fortún
dc.creatorm. Almela
dc.creatora. Moreno
dc.creatorLigia Camera Pierrotti
dc.creatorl. Linares
dc.creatorD.d. Gasperina
dc.creatorM.l. Balsamo
dc.creatorc Rovelli
dc.creatore. Concia
dc.creators. Chiesi
dc.creatorD.n. Salerno
dc.creatord. Ogunc
dc.creatorb. Pilmis
dc.date.accessioned2023-07-03T23:01:37Z
dc.date.accessioned2025-09-08T23:59:44Z
dc.date.available2023-07-03T23:01:37Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doi10.1111/ajt.15769
dc.identifier.issn16006135
dc.identifier.urihttps://hdl.handle.net/1843/55714
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAmerican Journal of Transplantation
dc.rightsAcesso Aberto
dc.subjectFarmacorresistência Fúngica
dc.subjectPesquisa em Enfermagem Clínica
dc.subjectInfectologia
dc.subjectTransplante de orgãos
dc.subject.otherAntibiotic drug resistance
dc.subject.otherClinical research/practice
dc.subject.otherInfection and infectious agents-bacterial
dc.subject.otherInfectious disease
dc.subject.otherOrgan transplantation in general
dc.titlePredictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia
dc.typeArtigo de periódico
local.citation.epage1641
local.citation.spage1629
local.citation.volume9
local.description.resumoTreatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multina tional, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the fol lowing variables: INCREMENT-CPE mortality score ≥8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score ≥8 and CMV disease (minus 7 points). This score showed an area under the receiver operat ing characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combi nation therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortal ity risk strata. A score-based algorithm is provided for therapy guidance.
local.identifier.orcidhttps://orcid.org/0000-0003-0848-3740
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1600613522223624?via%3Dihub

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