Inhibition of nNOS in the paraventricular nucleus of hypothalamus decreases exercise-induced hyperthermia

Página do item simplificado
dc.creatorBruna Lima Costa Zuquim Nunan
dc.creatorLucas Rios Drummond
dc.creatorQuezia Teixeira Rodrigues
dc.creatorCarlos César Crestani
dc.creatorRaphael Escorsim Szawka
dc.creatorCândido Celso Coimbra
dc.creatorGlauber dos Santos Ferreira da Silva
dc.date.accessioned2023-07-14T19:31:39Z
dc.date.accessioned2025-09-09T00:51:04Z
dc.date.available2023-07-14T19:31:39Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2021.09.011
dc.identifier.issn03619230
dc.identifier.urihttps://hdl.handle.net/1843/56254
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrain Research Bulletin
dc.rightsAcesso Aberto
dc.subjectCorpo - Temperatura - Regulação
dc.subject.otherExercise thermoregulation
dc.subject.otherHypothalamus
dc.subject.otherPVN
dc.subject.otherNitric oxide
dc.subject.otherBody temperature
dc.subject.otherPhysical performance
dc.titleInhibition of nNOS in the paraventricular nucleus of hypothalamus decreases exercise-induced hyperthermia
dc.typeArtigo de periódico
local.citation.epage72
local.citation.spage64
local.citation.volume177
local.description.resumoThe paraventricular nucleus of the hypothalamus (PVN) is an important site for autonomic control, which integrates thermoregulation centers and sympathetic outflow to thermoeffector organs. PVN neurons express the neuronal isoform of nitric oxide synthase (nNOS) whose expression is locally upregulated by physical exercise. Thus, the aim of the present study was to evaluate the role of nNOS in the PVN in the exercise-induced hyperthermia. Seven days after surgery, male Wistar rats received bilateral intra-PVN microinjections of the selective nNOS inhibitor Nw-Propyl-L-Arginine (NPLA) or vehicle (saline) and were submitted to an acute progressive exercise session on a treadmill until fatigue. Abdominal and tail skin temperature (Tabd and Ttail, respectively) were measured, and the threshold (Hthr; °C) and sensitivity (Hsen) for heat dissipation calculated. Performance variables were also collected. During the progressive exercise protocol, all animals displayed an increase in the Tabd. However, compared to vehicle group, the microinjection of NPLA in the PVN attenuated the exercise-induced hyperthermia. There was no difference in Ttail or Hthr between NPLA and control rats. In contrast, Hsen was increased in the NPLA group compared to vehicle. In addition, heat storage was lower in NPLA-treated animals. Despite the temperature differences, inhibition of nNOS in the PVN did not affect running performance on the treadmill. These results suggest that nitrergic signaling within the PVN, under nNOS activation, drives the increase of body temperature, being necessary for the proper thermal regulatory mechanisms during progressive exercise-induced hyperthermia.
local.identifier.orcidhttps://orcid.org/0000-0002-6042-7757
local.identifier.orcidhttps://orcid.org/0000-0003-3998-4169
local.identifier.orcidhttps://orcid.org/0000-0002-1942-858X
local.identifier.orcidhttps://orcid.org/0000-0002-2639-3469
local.identifier.orcidhttps://orcid.org/0000-0001-8981-6724
local.identifier.orcidhttps://orcid.org/0000-0002-6269-7443
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0361923021002744?via%3Dihub

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Inhibition of nNOS in the paraventricular nucleus of hypothalamus decreases exercise-induced hyperthermia.pdf
Tamanho:
28.1 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG