Millipore xmap® luminex (hatmag-68k): an accurate and cost-effective method for evaluating alzheimer's biomarkers in cerebrospinal fluid

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dc.creatorErika Oliveirahansen
dc.creatorAloisio Joaquim Freitas Ribeiro
dc.creatorBernardo Mattos Viana
dc.creatorMaria Aparecida Camargos Bicalho
dc.creatorNatalia Silva Dias
dc.creatorIvonne Carolina Bolaños Burgos
dc.creatorMonica Vieira Costa
dc.creatorAndréa Teixeira Carvalho
dc.creatorAntonio Lucio Teixeira
dc.creatorIzabela Guimarães Barbosa
dc.creatorLorena Aline Valu Santos
dc.creatorDaniela Valadão Freitas Rosa
dc.date.accessioned2023-07-18T19:33:12Z
dc.date.accessioned2025-09-09T00:22:06Z
dc.date.available2023-07-18T19:33:12Z
dc.date.issued2021-08-31
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fpsyt.2021.716686
dc.identifier.issn16640640
dc.identifier.urihttps://hdl.handle.net/1843/56602
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Psychiatry
dc.rightsAcesso Aberto
dc.subjectDoença de Alzheimer
dc.subjectProteínas tau
dc.subject.otherAlzheimer’s disease
dc.subject.otherbiomarker, Millipore xMap
dc.subject.other® Luminex, cerebrospinal fluid
dc.subject.otherAβ42
dc.subject.othertau
dc.subject.otherINNOTEST
dc.titleMillipore xmap® luminex (hatmag-68k): an accurate and cost-effective method for evaluating alzheimer's biomarkers in cerebrospinal fluid
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume12
local.description.resumoBackground: Alzheimer’s disease (AD) biomarkers are of great relevance in clinical research, especially after the AT(N) framework. They enable early diagnosis, disease staging and research with new promising drugs, monitoring therapeutic response.However, the high cost and low availability of the most well-known methods limits their use in low and medium-income countries. In this context, Millipore xMap® Luminex may be a cost-effective alternative. In our study, using INNOTEST® as reference, we assess the diagnostic accuracy of Millipore xMap® and propose a cutoff point for AD. Methods: We performed lumbar puncture of seven older individuals with clinically defined AD, 17 with amnestic mild cognitive impairment (aMCI) and 11 without objective cognitive impairment-control group (CG). Cerebrospinal fluid (CSF) biomarkers concentrations for aB42, p-Tau, and t-Tau were measured by INNOTEST® and Millipore xMap®, and then the techniques were compared to assess the diagnostic accuracy of the new test and to define a cutoff. Results: INNOTEST® and Millipore xMap® measurements showed all correlations >0.8 for the same biomarker, except for t-Tau that was 0.66. Millipore xMap® measurements showed a robust accuracy for all biomarkers, with AUC higher than 0.808 (t-Tau), and the best for Aβ42 (AUC = 0.952). The most accurate cutoffs were found at 1012.98 pg/ml (Aβ42), 64.54 pg/ml (p-tau), 3251.81 pg/ml (t-tau), 3.370 (t-Tau/Aβ42), and 0.059 (p-Tau/Aβ42). Conclusion: Given its good accuracy and cost-effectiveness, Milliplex xMap® tests seems a reliable and promising tool, especially for low and middle-income countries.
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.716686/full

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