An esculetin-cobalt(III) archetype for redox-activated drug delivery platforms with hypoxic selectivity

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dc.creatorRenata Crispim Batista
dc.creatorCarlos Basílio Pinheiro
dc.creatorFabio da Silva Miranda
dc.creatorMauricio Lanznaster
dc.date.accessioned2023-07-31T11:50:02Z
dc.date.accessioned2025-09-09T01:09:46Z
dc.date.available2023-07-31T11:50:02Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.identifier.doihttps://doi.org/10.1002/ejic.201701251
dc.identifier.issn1099-0682
dc.identifier.urihttps://hdl.handle.net/1843/57196
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Inorganic Chemistry
dc.rightsAcesso Restrito
dc.subjectCobalto
dc.subject.otherEsculetin–cobalt
dc.subject.otherRedox-activated drug delivery platform
dc.titleAn esculetin-cobalt(III) archetype for redox-activated drug delivery platforms with hypoxic selectivity
dc.typeArtigo de periódico
local.citation.epage616
local.citation.issue5
local.citation.spage612
local.citation.volume2018
local.description.resumoThe motivation of this work was to probe whether coordination of esculetin to cobalt(III) could lead to a complex with the required properties to function as a redox-activated drug delivery platform, selective for hypoxic environments. The complex [Co(esc)(py2en)]ClO4·(CH3OH)2 (1) was obtained and fully characterized by CHN elemental analysis, single-crystal X-ray diffractometry, UV/Vis and fluorescence spectroscopy, and ESI mass spectrometry. The redox behavior of 1 was evaluated by cyclic and square wave voltammetry analyses in MeCN and PBS buffer, which revealed distinct potentials for the Co3+/Co2+ processes in aqueous and organic solutions. In PBS, the potential is within the accepted ideal range (–0.2 to –0.4 V vs. SHE) for reduction in biological systems. Thus, a selective release of the coumarin ligand in a hypoxic environment upon reduction was simulated by investigating reactions of 1 with sodium dithionite in argon-, air-, and O2-saturated atmospheres. An [O2]-dependent dissociation of esculetin was monitored over a 72 h period at 25 °C by UV/Vis spectroscopy and confirmed by fluorescence spectroscopy and ESI-MS data. These results provide strong evidence of a hypoxia-selective, redox-activated mechanism for the release of esculetin from this cobalt(III) complex.
local.identifier.orcidhttps://orcid.org/0000-0002-8674-1779
local.identifier.orcidhttps://orcid.org/0000-0001-9977-242X
local.identifier.orcidhttps://orcid.org/0000-0003-0477-0152
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.201701251

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