Influência do consumo de diferentes fontes de gordura no perfil bioquímico e imunológico

Abstract

Obesity is defined as an excessive accumulation of body fat, originated from a positive energy balance. It is associated with a chronic inflammation in the metabolic tissues characterized by abnormal secretion of mediators of the immune response and activation of inflammatory signaling pathways. Many studies have shown that factors associated with diet are important in the modulation of the adiposity increase, highlighting the link between nutrition, metabolism and immune system. Thus, the present study aimed to evaluate the biochemical and immunological profile in mice of the strain C57BL/6 correlated with the main sources of ingested fat. C57BL/6 mice were divided into 4 groups: AIN93G (normal diet), HSB (diet high in sugar and butter), HSL (diet high in sugar and lard) and HSO (diet high in sugar and olive oil olive). After 8 weeks of treatment, animals were euthanized. Weight gain, adiposity, biochemical and immunological parameters (cytokines and adipokines) were assessed. Our data suggest that the type of the fat ingested interfere with biochemical and immunologic profiles in animals, but there is still a need for more detailed studies regarding the function of each lipid component by itself as well as in conjunction with other nutrients that comprise dietary fats.