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http://hdl.handle.net/1843/39631| Type: | Artigo de Periódico |
| Title: | Adipokines, inflammatory and insulin resistance parameters may not be good markers of metabolic syndrome following liver transplant |
| Authors: | Lucilene Rezende Anastácio Marina Chaves de Oliveira Kiara Gonçalves Diniz Adaliene Matos Versiane Ferreira Agnaldo Soares Lima Maria Isabel Toulson Davisson Correia Eduardo Garcia Vilela |
| Abstract: | Objective The role of adipokines in liver transplantation (LTx) recipients who have metabolic syndrome (MetS) has seldom been assessed. The aim of this study was to investigate the concentrations of adipokines, inflammatory mediators, and insulin-resistance markers in liver recipients with MetS and its components. Methods Serum samples from 34 patients (55.9% male; 54.9 ± 13.9 y; 7.7 ± 2.9 y after LTx; 50% presented with MetS) were assessed for adiponectin, resistin, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, C-reactive protein (CRP), homeostatic model assessment-insulin resistance (HOMA-IR) and free fatty acid (FFA) levels. The dosages were uni- and multivariate analyzed to cover MetS (using the Harmonizing MetS criteria), its components, and dietary intake. Results A higher concentration of adiponectin (P < 0.05) was observed among patients with MetS (5.2 ± 3.2 μg/mL) compared with those without MetS (3.2 ± 1.2 μg/mL), as well as those with MetS components versus those without them: abdominal obesity (4.6 ± 2.6 μg/mL versus 2.6 ± 0.6 μg/mL), high triacylglycerols (TGs; 5.6 ± 3.1 μg/mL versus 3 ± 0.9 μg/mL) and low high-density lipoprotein (HDL; 6.1 ± 2.7 μg/mL versus 3.3 ± 1.9 μg/mL). Increased TNF-α and HOMA-IR values were seen in patients with abdominal obesity. Patients with high TGs also had greater FFA values. Independent predictors for adiponectin were waist-to-hip ratio, low HDL and high TGs. High TGs and fasting blood glucose were independent predictors for HOMA-IR. Independent predictors could not be identified for CRP, TNF-α, MCP-1, IL-6, or FFA. Conclusions MetS and its components are related to an increased HOMA-IR concentration and FFA. Adiponectin, resistin, and inflammatory markers, such as TNF-α, IL-6, MCP-1, and CRP, were not associated with MetS in this sample of post-LTx patients. |
| Subject: | Transplante Fígado |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO FAR - DEPARTAMENTO DE ALIMENTOS MED - DEPARTAMENTO DE CIRURGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1016/j.nut.2015.12.038 |
| URI: | http://hdl.handle.net/1843/39631 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/abs/pii/S0899900715005353?via%3Dihub |
| metadata.dc.relation.ispartof: | Nutrition |
| Appears in Collections: | Artigo de Periódico |
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