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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39765
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dc.creatorAngélica Thomaz Vieirapt_BR
dc.creatorIzabela Galvãopt_BR
dc.creatorLaurence M. Maciapt_BR
dc.creatorÉrica Moraes Sernagliapt_BR
dc.creatorMarco Aurélio Ramirez Vinolopt_BR
dc.creatorCristiana Couto Garciapt_BR
dc.creatorLuciana Pádua Tavarespt_BR
dc.creatorFlávio Almeida Amaralpt_BR
dc.creatorLirlândia Pires de Sousapt_BR
dc.creatorFlaviano dos Santos Martinspt_BR
dc.creatorCharles Reay Mackaypt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.date.accessioned2022-03-01T20:01:42Z-
dc.date.available2022-03-01T20:01:42Z-
dc.date.issued2017-
dc.citation.volume101pt_BR
dc.citation.issue1pt_BR
dc.citation.spage275pt_BR
dc.citation.epage284pt_BR
dc.identifier.doihttps://doi.org/10.1189/jlb.3A1015-453RRRpt_BR
dc.identifier.issn1938-3673pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39765-
dc.description.resumoGout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception. The onset of inflammatory response induced by MSU crystals was not altered in animals given a high-fiber diet, but the high-fiber diet induced faster resolution of the inflammatory response. Similar results were obtained in animals given the SCFA acetate. Acetate was effective, even when given after injection of MSU crystals at the peak of the inflammatory response and induced caspase-dependent apoptosis of neutrophils that accounted for the resolution of inflammation. Resolution of neutrophilic inflammation was associated with decreased NF-κB activity and enhanced production of anti-inflammatory mediators, including IL-10, TGF-β, and annexin A1. Acetate treatment or intake of a high-fiber diet enhanced efferocytosis, an effect also observed in vitro with neutrophils treated with acetate. In conclusion, a high-fiber diet or one of its metabolic products, acetate, controls the inflammatory response to MSU crystals by favoring the resolution of the inflammatory response. Our studies suggest that what we eat plays a determinant role in our capacity to fine tune the inflammatory response.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Leukocyte Biologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherFibras na dietapt_BR
dc.subject.otherGotapt_BR
dc.subject.otherInflamaçãopt_BR
dc.titleDietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in micept_BR
dc.typeArtigo de Periódicopt_BR
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