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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40135
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dc.creatorRafael Wesley Bastospt_BR
dc.creatorSílvia Helena Sousa Pietra Pedrosopt_BR
dc.creatorAngélica Thomaz Vieirapt_BR
dc.creatorLuciana Mara Costa Moreirapt_BR
dc.creatorC. S. Françapt_BR
dc.creatorChristiane Teixeira Cartellept_BR
dc.creatorRosa Maria Esteves Arantespt_BR
dc.creatorSimone de Vasconcelos Generosopt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorMaria José Nevespt_BR
dc.creatorJacques Robert Nicolipt_BR
dc.creatorFlaviano dos Santos Martinspt_BR
dc.date.accessioned2022-03-15T21:48:53Z-
dc.date.available2022-03-15T21:48:53Z-
dc.date.issued2016-
dc.citation.volume7pt_BR
dc.citation.issue4pt_BR
dc.citation.spage549pt_BR
dc.citation.epage557pt_BR
dc.identifier.doihttps://doi.org/10.3920/BM2015.0190pt_BR
dc.identifier.issn1876-2891pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40135-
dc.description.resumoIndigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice. Only post-treatment with viable Sc-905 was able to protect mice against the damage caused by chemotherapy, reducing the weight loss, increase of intestinal permeability and jejunal lesions (villous shortening). Besides, this treatment reduced oxidative stress, prevented the decrease of goblet cells and stimulated the replication of cells in the intestinal crypts of mice with experimental mucositis. In conclusion, Sc-905 protects animals against irinotecan-induced mucositis when administered as a post-treatment with viable cells, and this effect seems to be related with the reduction of oxidative stress and preservation of intestinal mucosa.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBeneficial Microbespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectProbioticpt_BR
dc.subjectSaccharomyces cerevisiae UFMG A-905pt_BR
dc.subjectChemotherapypt_BR
dc.subjectMucositispt_BR
dc.subjectOxidative stresspt_BR
dc.subject.otherProbióticospt_BR
dc.subject.otherSaccharomyces cerevisiaept_BR
dc.subject.otherTratamento farmacológicopt_BR
dc.subject.otherMucositept_BR
dc.subject.otherEstresse oxidativopt_BR
dc.titleSaccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.wageningenacademic.com/doi/abs/10.3920/BM2015.0190pt_BR
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