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http://hdl.handle.net/1843/40135| Type: | Artigo de Periódico |
| Title: | Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis |
| Authors: | Rafael Wesley Bastos Sílvia Helena Sousa Pietra Pedroso Angélica Thomaz Vieira Luciana Mara Costa Moreira C. S. França Christiane Teixeira Cartelle Rosa Maria Esteves Arantes Simone de Vasconcelos Generoso Valbert Nascimento Cardoso Maria José Neves Jacques Robert Nicoli Flaviano dos Santos Martins |
| Abstract: | Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice. Only post-treatment with viable Sc-905 was able to protect mice against the damage caused by chemotherapy, reducing the weight loss, increase of intestinal permeability and jejunal lesions (villous shortening). Besides, this treatment reduced oxidative stress, prevented the decrease of goblet cells and stimulated the replication of cells in the intestinal crypts of mice with experimental mucositis. In conclusion, Sc-905 protects animals against irinotecan-induced mucositis when administered as a post-treatment with viable cells, and this effect seems to be related with the reduction of oxidative stress and preservation of intestinal mucosa. |
| Subject: | Probióticos Saccharomyces cerevisiae Tratamento farmacológico Mucosite Estresse oxidativo |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.3920/BM2015.0190 |
| URI: | http://hdl.handle.net/1843/40135 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.wageningenacademic.com/doi/abs/10.3920/BM2015.0190 |
| metadata.dc.relation.ispartof: | Beneficial Microbes |
| Appears in Collections: | Artigo de Periódico |
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