Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/40147| Type: | Artigo de Periódico |
| Title: | Tissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort study |
| Authors: | Luci Maria SantAna Dusse Lara Carvalho Godoi Karina Braga Gomes Borges Maria das Graças Carvalho Bashir Abdulgader Lwaleed |
| Abstract: | Previously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women (n = 79), normotensive pregnant women (n = 80) and women with severe P-EC (n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women (P < 0.01) or normotensive pregnant women (P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women (P < 0.01). However, no such significant trends were observed for plasma TF levels (P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity. |
| Subject: | Sangue Fator VII Fator VIIa Plasma Pré-eclâmpsia Complicações na gravidez Tromboplastina |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1097/MBC.0000000000000507 |
| URI: | http://hdl.handle.net/1843/40147 |
| Issue Date: | Jun-2016 |
| metadata.dc.url.externa: | https://journals.lww.com/bloodcoagulation/Abstract/2016/06000/Tissue_factor_dependent_pathway_in_severe.14.aspx |
| metadata.dc.relation.ispartof: | Blood Coagulation and Fibrinolysis |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.