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http://hdl.handle.net/1843/40631| Type: | Artigo de Periódico |
| Title: | Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
| Authors: | Luciana Flávia de Almeida Romani Maria Irene Yoshida Elionai Cassiana de Lima Gomes Renes de Resende Machado Felipe Fernandes Rodrigues Márcio de Matos Coelho Marcelo Antônio de Oliveira Maria Betânia de Freitas-Marques Rosane Aguiar da Silva San Gil Wagner da Nova Mussel |
| Abstract: | Meloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and 1H NMR spectra showed characteristic assignments. 13C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies, as a routine procedure, to ensure the desired dose/effect. |
| Subject: | Química Farmácia de manipulação Farmácia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1016/j.jpha.2017.12.006 |
| URI: | http://hdl.handle.net/1843/40631 |
| Issue Date: | Apr-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2095177917301399 |
| metadata.dc.relation.ispartof: | Journal of Pharmaceutical Analysis |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples.pdf | 1.58 MB | Adobe PDF | View/Open |
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