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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40672
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dc.creatorLarissa Gabriela Ferreira de Carvalhopt_BR
dc.creatorWilliam Gustavo Limapt_BR
dc.creatorLuiz Gonzaga Vaz Coelhopt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.date.accessioned2022-03-31T20:29:29Z-
dc.date.available2022-03-31T20:29:29Z-
dc.date.issued2021-02-25-
dc.citation.volume27pt_BR
dc.citation.issue2pt_BR
dc.citation.spage169pt_BR
dc.citation.epage181pt_BR
dc.identifier.doi10.1093/ibd/izaa037pt_BR
dc.identifier.issn1078-0998pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40672-
dc.description.resumoBackground The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 > 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInflammatory Bowel Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAdipokinespt_BR
dc.subjectCrohn’s diseasept_BR
dc.subjectUlcerative colitispt_BR
dc.subjectPrognosispt_BR
dc.subjectDifferential diagnosispt_BR
dc.subject.otherDoenças inflamatórias intestinaispt_BR
dc.subject.otherRevisão sistemáticapt_BR
dc.titleCirculating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/ibdjournal/article/27/2/169/5756067pt_BR
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