Please use this identifier to cite or link to this item:
Type: Artigo de Periódico
Title: Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
Authors: Larissa Gabriela Ferreira de Carvalho
William Gustavo Lima
Luiz Gonzaga Vaz Coelho
Valbert Nascimento Cardoso
Simone Odília Antunes Fernandes
Abstract: Background The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 > 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.
Subject: Doenças inflamatórias intestinais
Revisão sistemática
language: eng Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAR - DEPARTAMENTO DE ALIMENTOS
Rights: Acesso Aberto
metadata.dc.identifier.doi: 10.1093/ibd/izaa037
Issue Date: 25-Feb-2021
metadata.dc.relation.ispartof: Inflammatory Bowel Diseases
Appears in Collections:Artigo de Periódico

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.