Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/40864| Type: | Artigo de Periódico |
| Title: | Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method |
| Authors: | Marina Ferrara de Resende Cleudiomar Inácio Lino Elaine Maria de Souza-Fagundes João Vitor Paes Rettore Renata Barbosa de Oliveira Renata Adriana Labanca |
| Abstract: | Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature. |
| Subject: | Diabetes mellitus Curcumina |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/s2175-97902019000118218 |
| URI: | http://hdl.handle.net/1843/40864 |
| Issue Date: | Jun-2019 |
| metadata.dc.url.externa: | https://www.scielo.br/j/bjps/a/9jk3vMCmNjfjMKrLLBWrfDL/?lang=en |
| metadata.dc.relation.ispartof: | Brazilian Journal of Pharmaceutical Sciences |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative in vitro and in vivo method.pdf | 1.18 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.