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Type:	Artigo de Periódico
Title:	Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
Authors:	Stephanie de Souza Theodoro Thaila Cristina Putarov Caroline Tiemi Lara Mantovani Volpe Carlos Alberto Ferreira de Oliveira Maria Beatriz de Abreu Glória Aulus Cavalieri Carciofi
Abstract:	Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and solublepreparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional andanother with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used,divided into the following treatments: CON–control, without yeast cell wall addition; YCW–addition of 0.3% of a conventional yeascell wall extract; YCWs–addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagledogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production ofhydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at thebeginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products werequantified. The results were evaluated by analysis of variance and compared using the Tukey test (P<0.05), using the basalimmunological parameters as a covariate. The inclusion of YCWs reduced fat digestibility (P<0.05), increased the concentration ofbutyrate and putrescine, and reduced lactate in feces (P<0.05), showing that mannan oligosaccharide solubilization resulted inhigher fermentation of this compound and altered the metabolism of the gut microbiota. Lower IL-6 on serum was verified for dogsfed the YCWs diet (P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher phagocytic index was verified forperipheral monocytes after the intake of the YCW food, suggesting better innate immunity. In conclusion, the solubilization of themannooligosaccharide fraction alters its interaction with gut microbiota and biological actions in animals, although both yeast cellwall preparations exhibited prebiotic effects on dogs.
Subject:	Ciência e Tecnologia de Alimentos Medicina Veterinária Cachorros
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1371/journal.pone.0225659
URI:	http://hdl.handle.net/1843/40865
Issue Date:	Nov-2019
metadata.dc.url.externa:	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225659
metadata.dc.relation.ispartof:	Plos one
Appears in Collections:	Artigo de Periódico

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