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http://hdl.handle.net/1843/41626| Type: | Artigo de Periódico |
| Title: | Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice |
| Authors: | Flavia Mendes Peradeles Galdino Maria Emília Rabelo Andrade Patrícia Aparecida Vieira de Barros Simone de Vasconcelos Generoso Jacqueline Isaura Alvarez-Leite Camila Megale de Almeida-Leite Maria do Carmo Gouveia Peluzio Simone Odília Antunes Fernandes Valbert Nascimento Cardoso |
| Abstract: | Mucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P < 0.05). FOS supplementation attenuated all these parameters (P < 0.05). Only pretreatment was able to maintain the acetate and butyrate production. These results showed that FOS supplementation presented protective effects on intestinal barrier function. |
| Subject: | Mucosite intestinal Permeabilidade intestinal fruto-oligossacarídeo Camundongos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1016/j.jff.2018.09.012 |
| URI: | http://hdl.handle.net/1843/41626 |
| Issue Date: | Oct-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1756464618304869?via%3Dihub#! |
| metadata.dc.relation.ispartof: | Journal of Functional Foods |
| Appears in Collections: | Artigo de Periódico |
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