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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41750
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dc.creatorWilliam Gustavo de Limapt_BR
dc.creatorGeisa Cristina Silva Alvespt_BR
dc.creatorCristina Sanchespt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorMagna Cristina de Paivapt_BR
dc.date.accessioned2022-05-17T14:02:48Z-
dc.date.available2022-05-17T14:02:48Z-
dc.date.issued2019-11-
dc.citation.volume45pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1495pt_BR
dc.citation.epage1508pt_BR
dc.identifier.doi10.1016/j.burns.2019.07.006pt_BR
dc.identifier.issn0305-4179pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41750-
dc.description.resumoPurpose In this study, we aimed reviewed the data about the patterns of antimicrobial susceptibility and resistance determinants among carbapenem-resistant Acinetobacter baumannii (CRAB) from patients with burn injury. Methods A systematic review was conducted using the PRISMA statement in PUBMED/MEDLINE, Scopus, Scientific Electronic Library Online (SciELO), Biblioteca Virtual de Saúde (BVS) and Cochrane Library. The data referring to enzymatic resistance mechanisms were evaluated by meta-analyses according to random effect. Results 17 articles that evaluated 1226 CRAB recovered from patients with burn injury were included in study. The majority of studies are from Iran (12/17; 70.6%), published in 2016 (6/17; 35.3%) and showed prospective design (15/17; 88.2%). The samples were obtained mainly from burn wounds (14/17; 82.3%) and more than half of the studies did not identify if the isolates originated from infected or colonized patients (10/17; 58.8%). Second the meta-analyses, OXA-type carbapenemase was the main mechanism involved in low susceptibility to carbapenems (53.2%; 95% CI = 60, 80.0%, I2 = 86.0%), followed by metallo-β-lactamases (MBL) (30.2%; 95% CI = 11, 42.0%, I2 = 93.0%), and Klebsiella pneumoniae carbapenemase (KPC) (16.6%; 95% CI = 5, 63.0%, I2 = 88.0%). The majority of strains harbored blaOXA-23-like (12/17; 70.6%) or blaOXA-24/40-like (12/17; 35.3%) genes. The studies included showed that minocycline (69.5%) and colistin (99.9%) susceptibility remains high and is not impacted by carbapenem resistance in these isolates. Conclusions The results summarized in this review indicate the importance of a high-quality surveillance program to design suitable and effective interventions to control CRAB infection in burn units worldwide.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBurnspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectColistinpt_BR
dc.subjectMinocyclinept_BR
dc.subjectBurn unitspt_BR
dc.subjectHealthcare-associated infectionspt_BR
dc.subjectMulti-drug resistancept_BR
dc.subjectAcinetobacter baumanniipt_BR
dc.subject.otherRevisão sistemáticapt_BR
dc.subject.otherPacientept_BR
dc.subject.otherQueimadurapt_BR
dc.subject.otherAcinetobacter baumanniipt_BR
dc.titleCarbapenem-resistant Acinetobacter baumannii in patients with burn injury: a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0305417919300282?via%3Dihubpt_BR
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