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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41807
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dc.creatorFernanda Alves Abrantespt_BR
dc.creatorBruna Bernardo Nascimentopt_BR
dc.creatorMaria Emília Rabelo Andradept_BR
dc.creatorPatrícia Aparecida Vieira de Barrospt_BR
dc.creatorChristiane Teixeira Cartellept_BR
dc.creatorFlaviano dos Santos Martinspt_BR
dc.creatorJacques Robert Nicolipt_BR
dc.creatorRosa Maria Esteves Arantespt_BR
dc.creatorSimone de Vasconcelos Generosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.date.accessioned2022-05-18T21:48:45Z-
dc.date.available2022-05-18T21:48:45Z-
dc.date.issued2019-02-
dc.citation.volume11pt_BR
dc.citation.issue1pt_BR
dc.citation.spage47pt_BR
dc.citation.epage57pt_BR
dc.identifier.doi10.3920/bm2019.0098pt_BR
dc.identifier.issn1876-2883pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41807-
dc.description.resumoThis study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bifidobacterium only during disease induction (7 days); total treatment (TT) group, mice received Bifidobacterium for 10 days before and during disease induction. The probiotic effects on intestinal permeability, inflammatory infiltrate, histological analysis, cytokines, chemokines and sIgA were evaluated. Bifidobacterium administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (P<0.05). Bifidobacterium administration in the TT group attenuated severe lesions in the colon and reduced eosinophil peroxidase level (P<0.05). B. longum 51A treatment modality was more effective than total treatment and reduced the inflammatory response and its consequences on intestinal epithelium.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBeneficial Microbespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBifidobacterium longum 51Apt_BR
dc.subjectColitispt_BR
dc.subjectIntestinal epitheliumpt_BR
dc.subjectInflammatory bowel diseasespt_BR
dc.subjectProbioticpt_BR
dc.subject.otherDoenças inflamatórias intestinaispt_BR
dc.subject.otherBifidobacteriumpt_BR
dc.subject.otherColitept_BR
dc.titleTreatment with Bifidobacterium longum 5 1A attenuates intestinal damage and inflammatory response in experimental colitispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.wageningenacademic.com/doi/10.3920/BM2019.0098pt_BR
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