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http://hdl.handle.net/1843/41807| Type: | Artigo de Periódico |
| Title: | Treatment with Bifidobacterium longum 5 1A attenuates intestinal damage and inflammatory response in experimental colitis |
| Authors: | Fernanda Alves Abrantes Bruna Bernardo Nascimento Maria Emília Rabelo Andrade Patrícia Aparecida Vieira de Barros Christiane Teixeira Cartelle Flaviano dos Santos Martins Jacques Robert Nicoli Rosa Maria Esteves Arantes Simone de Vasconcelos Generoso Simone Odília Antunes Fernandes Valbert Nascimento Cardoso |
| Abstract: | This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bifidobacterium only during disease induction (7 days); total treatment (TT) group, mice received Bifidobacterium for 10 days before and during disease induction. The probiotic effects on intestinal permeability, inflammatory infiltrate, histological analysis, cytokines, chemokines and sIgA were evaluated. Bifidobacterium administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (P<0.05). Bifidobacterium administration in the TT group attenuated severe lesions in the colon and reduced eosinophil peroxidase level (P<0.05). B. longum 51A treatment modality was more effective than total treatment and reduced the inflammatory response and its consequences on intestinal epithelium. |
| Subject: | Doenças inflamatórias intestinais Bifidobacterium Colite |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.3920/bm2019.0098 |
| URI: | http://hdl.handle.net/1843/41807 |
| Issue Date: | Feb-2019 |
| metadata.dc.url.externa: | https://www.wageningenacademic.com/doi/10.3920/BM2019.0098 |
| metadata.dc.relation.ispartof: | Beneficial Microbes |
| Appears in Collections: | Artigo de Periódico |
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