Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41870
Type: Artigo de Periódico
Title: Pharmaceutical and biomedical applications of native and modified starch: a review
Authors: Maria Aparecida Vieira Teixeira Garcia
Cleverson Fernando Garcia
André Augusto Gomes Faraco
Abstract: Starch is a natural, renewable, and biodegradable polymer produced by many plants as a source of stored energy. The structural and functional diversity of starches makes them suitable for different applications. Various physical, chemical, and enzymatic modifications can change and improve functional properties of starch to facilitate its use for different pharmaceutical purposes. Currently, some types of starches—for example, native starch, sodium starch glycolate (chemically modified starch), and pregelatinized starch (physically modified starch)—are approved by the United States Food and Drug Administration (FDA) for use either as an isolated excipient or as a matrix for drug delivery systems in granules, capsules, tablets, suppositories, implants, stents, transdermal, and ophthalmic systems. However, the increasing number of drug moieties with varying physicochemical and stability properties along with the development of new drug production processes and drug delivery systems exert pressure on formulators to search for new excipients that achieve the desired set of functionalities. This paper offers a clear overview of native and modified starches and their use in pharmaceutical and biomedical applications, either as excipients or as drug delivery systems. In addition, some drug release mechanisms, which include encapsulants, micro/nanoparticles hydrogels and scaffolds, are discussed.
Subject: Amido
Amido nativo
Amido modificado
Aplicações farmacêuticas
Aplicações biomédicas
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAR - DEPARTAMENTO DE ALIMENTOS
FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
Rights: Acesso Restrito
metadata.dc.identifier.doi: 10.1002/star.201900270
URI: http://hdl.handle.net/1843/41870
Issue Date: Jul-2020
metadata.dc.url.externa: https://onlinelibrary.wiley.com/doi/full/10.1002/star.201900270
metadata.dc.relation.ispartof: Starch - Stärke
Appears in Collections:Artigo de Periódico

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