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http://hdl.handle.net/1843/41938| Tipo: | Artigo de Periódico |
| Título: | Rate of polymyxin resistance among Acinetobacter baumannii recovered from hospitalized patients: a systematic review and meta-analysis |
| Autor(es): | William Gustavo Lima Júlio César Moreira Brito Bárbara Gatti Cardoso Valbert Nascimento Cardoso Magna Cristina de Paiva Maria Elena de Lima Simone Odília Antunes Fernandes |
| Resumen: | We conducted a systematic review and meta-analysis to determine the rate of polymyxin resistance among Acinetobacter baumannii isolates causing infection in hospitalized patients around the world during the period of 2010-2019. The systematic review was performed on September 1, 2019, using PubMed/MEDLINE, Scopus, and Web of Science; studies published after January 1, 2010, were selected. The data were summarized in tables, critically analyzed, and treated statistically using the RStudio® Software with Meta package and Metaprop Command. After applying exclusion factors, 41 relevant studies were selected from 969 articles identified on literature search. The overall rate of polymyxin-resistant A. baumannii (PRAB) related to hospitalized patients was estimated to be 13% (95% CI, 0.06-0.27), where a higher rate was observed in America (29%; 95% CI, 0.12-0.55), followed by Europe (13%; 95% CI, 0.02-0.52), and Asia (10%; 95% CI, 0.02-0.32). The extensive use of polymyxins on veterinary to control bacterial infection and growth promotion, as well as the resurgence in prescription and use of polymyxins in the clinics against carbapenem-resistant gram-negative bacteria, may have contributed to the increased incidence of PRAB. The findings of this meta-analysis revealed that the rate of PRAB recovered from hospitalized patients is distinctively high. Thus, action needs to be taken to develop strategies to combat the clinical incidence of PRAB-induced hospital infections. |
| Asunto: | Polimixinas Acinetobacter baumannii Pacientes Revisão sistemática Metanálise |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | 10.1007/s10096-020-03876-x |
| URI: | http://hdl.handle.net/1843/41938 |
| Fecha del documento: | 2020 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s10096-020-03876-x |
| metadata.dc.relation.ispartof: | European Journal of Clinical Microbiology & Infectious Diseases |
| Aparece en las colecciones: | Artigo de Periódico |
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