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http://hdl.handle.net/1843/41944| Type: | Artigo de Periódico |
| Title: | Nanonization techniques to overcome poor water-solubility with drugs |
| Authors: | Flávia Lidiane Oliveira da Silva Maria Betânia de Freitas Marques Kelly Cristina Kato Guilherme Carneiro |
| Abstract: | Introduction: Most drugs used in therapy have low water-solubility, a factor that could reduce their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical development. Nanonization of drugs is the reduction of particles to nanoscale, increasing the surface area and consequently the saturation solubility and dissolution rate and resulting in higher bioavailability. Areas covered: This review provides an overview of the consequences of the poor water-solubility and the main strategies applied to increase the solubility of poorly water-soluble drugs. The relationship between the biopharmaceutical classification system and the solubilization process of the drug is also considered. Finally, it includes how drug nanoparticles and nanocarriers, especially lipid-based nanosystems, can overcome these challenges and which of these approaches are already available on the market. Expert opinion: Due to the growing importance of nanomedicines, especially for applications in poorly water-soluble drugs, it is important to clearly establish the specifications and quality criteria for nanonized drugs to ensure the quality and safety of nanoparticles. |
| Subject: | Nanotecnologia Biodisponibilidade Sistemas de entrega de drogas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1080/17460441.2020.1750591 |
| URI: | http://hdl.handle.net/1843/41944 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.tandfonline.com/doi/full/10.1080/17460441.2020.1750591 |
| metadata.dc.relation.ispartof: | Expert Opinion on Drug Discovery |
| Appears in Collections: | Artigo de Periódico |
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