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http://hdl.handle.net/1843/42073| Tipo: | Artigo de Periódico |
| Título: | Biocompatibility assessment of fibrous nanomaterials in mammalian embryos |
| Autor(es): | Michele Munk Pereira Humberto de Mello Brandão Luiz Sérgio de Almeida Camargo Carolina Capobiango Romano Quintão Saulo R. Silva Eliza Diniz de Souza Nádia Rezende Barbosa Raposo José Manoel Marconcini Ado Jorio de Vasconcelos Luiz Orlando Ladeira |
| Resumen: | Currently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications. |
| Asunto: | Nanomateriais Biocompatibilidade Apoptose |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE FÍSICA |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | 10.1016/j.nano.2016.01.006 |
| URI: | http://hdl.handle.net/1843/42073 |
| Fecha del documento: | 2016 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1549963416000769?via%3Dihub |
| metadata.dc.relation.ispartof: | Nanomedicine: Nanotechnology, Biology and Medicine |
| Aparece en las colecciones: | Artigo de Periódico |
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