Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42345
Type: Artigo de Periódico
Title: Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae
Authors: Emerson Ribeiro Lima
L. L. S. Cardoso
Alessandra Rejane Ericsson de Oliveira Xavier
Adriana Amaral Carvalho
Mauro Aparecido de Sousa Xavier
Hadison Santos Nogueira Curzio
Higor Rabelo Guedes
Luciano Freitas Fernandes
Anna Christina de Almeida
Elytania Veiga Menezes
Nair Amélia Prates Barreto
Abstract: We characterized six drug-resistant nosocomial isolates of Klebsiella pneumoniae obtained in a hospital located in northern Minas Gerais State, Brazil, by determining their antibiotic sensitivity profiles, detecting the blaKPC genetic marker and examining their clonal relationships. All isolates were found to be extensively drug resistant. A PCR assay was used to confirm the identity of the isolates as K. pneumoniae and assess the blaKPC gene. All isolates tested positive for the blaKPC gene, which is related to carbapenem resistance. The genetic profiles and clonal relationships among the isolates were evaluated by ERIC-PCR. All the isolates were in a single group with two distinct subgroups. Analysis of the genetic diversity among the isolates revealed that five of the six were clones, which suggests cross-transmission in this hospital environment. Five of the patients died from infection. We describe the first detection of KPC-producing K. pneumoniae isolates from a hospital in northern Minas Gerais state.
Subject: Bacterias gram-negativas
Infecções por Bactérias Gram-Negativas
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
metadata.dc.identifier.doi: http://doi.org/10.4238/GMR18172
URI: http://hdl.handle.net/1843/42345
Issue Date: 2019
metadata.dc.url.externa: https://www.semanticscholar.org/paper/Research-Article-Characterization-and-molecular-of-Lima-Carvalho/ec00cd9bc4ae45027c20664729630a997b7218ca
metadata.dc.relation.ispartof: Genetics and Molecular Research
Appears in Collections:Artigo de Periódico



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