Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42348
Type: Artigo de Periódico
Title: Honey activity on the proliferation and migration of oral squamous cell carcinoma: in vitro and bioinformatic analysis
Authors: Eliane Macedo Sobrinho Santos
Kattyanne de Souza Costa
Andre Luiz Sena Guimaraes
Lucyana Conceiçao Farias
Hercules Otacílio Santos
Juliana Rezende Sá Miranda Goncalves
Anna Christina de Almeida
Igor Viana Brandi
Alex Sander Rodrigues Cangussu
Janainne Nunes Alves
Sabrina Ferreira de Jesus
Ricardo Jardim Neiva
Abstract: This study aimed to investigate, in oral squamous carcinoma cells (OSCC), the antineoplastic effect of Apis mellifera honey produced from Aroeira and wildflower, in the region of Jequitinhonha River Valley, Brazil. Furthermore, we investigate the molecular mechanism of honey performance through bioinformatic analysis. Honey and OSCC-related gene list were screened using GeneCards. The online tool STRING was used to identify the potential interaction networks of protein products of these genes. The genes with the highest weighted number of links (WNL) were called leader genes. GO and KEGG pathway analysis was performed to classify the genes. We use a search tool STITCH for interactions of chemicals-proteins. The chemical characterization of honey and its antiproliferative and antimigratory effects in SCC-9 cell lines was evaluated in vitro. The analysis of the interaction network obtained from the STRING database indicated by the following leader genes: TNF, IL6 and HDAC1. GO analysis for the honey, and OSCC-related proteins revealed that leader genes-regulated cancers genes were markedly enriched in some functions. Through the chemical characterization, the bioactive classes: steroids/triterpenoids, flavonoids, saponins, alkaloids, and tannins were identified. Polyphenols act in activating CASP3 and TP53 and inhibit the action of DNMT1. The honey produced from Aroeira and wildflower reduced proliferative phenotype and migration of OSCC cells.
Subject: Mel de abelha -- Jequitinhonha, Rio, Vale (MG e BA)
Aroeira do sertão
Abelha-européia
Mel -- Uso terapêutico
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
metadata.dc.identifier.doi: https://doi.org/10.5897/SRE2018.6590
URI: http://hdl.handle.net/1843/42348
Issue Date: 2018
metadata.dc.url.externa: https://academicjournals.org/journal/SRE/article-abstract/60EC8D659093i
metadata.dc.relation.ispartof: Scientific research and essays
Appears in Collections:Artigo de Periódico



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