Avaliação do efeito da 3-cloro-4-(p-clorofenilsulfonilamino)-5-hidroxifuran-2(5H)-ona na esteatose hepática em camundongos obesos

Abstract

The disease is corrective of the association of factors that results in excessive obesity of body fat. It currently represents a public health problem due to its epidemiological scope and association with other very prevalent pathologies such as arterial hypertension and type II diabetes mellitus. Also obesity or the development of metabolic obesity, among other causes, are related to the Renin Angio System. Fat deposition, metabolic syndrome (MS) and associated risks increase with aging, as well as metabolic comorbidities and obesity aggregation coefficients are responsible for causing morphological changes in liver tissue. The natural lactones of the representative type, but they present a great variety of biological species, and therefore their structures of inspiration for the preparation of a biological source of biological origin. Thus, the present study aims to evaluate the effect of the synthetic lactone 3-chloro-4-(p-chlorophenylsulfonylamino)-5-hydroxyfuran-2(5H)-one in the treatment of hepatic steatosis in obese mice. For the accomplishment of this study, 48 mice were used swiss males at eight weeks of age. Mice were randomly assigned to six groups, ST (standard group), ST+ATB (standard group + antibiotic), ST+LC (standard group + lactone), HFD (high-fat diet), HFD+ATB (high-fat diet + antibiotic), HFD+LC (high-fat diet + lactone). Obesity induction lasted four months and treatment with antibiotics and lactone lasted one month. The animals were weighed every three days throughout the period of MS induction and treatment, the fasting glucose test was performed, and food intake was evaluated daily. After the end of the treatment, the animals were weighed and euthanized by guillotine decapitation, and a liver sample was collected. Histological analyzes and liver weight were performed. The statistical significance of differences in mean values between groups were evaluated by factor ANOVA. The results demonstrate a decrease in the weight of the animals and the liver after treatment with synthetic lactone (HFD+LC), in addition to an improvement in the fasting glycemic profile in this group. It is concluded that synthetic lactone is relevant in the treatment of hepatic steatosis and obesity in animals, with significant histological improvement in liver adipocyte cells.