1. Repositório Institucional da UFMG
2. Publicações Científicas e Culturais
3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice
Authors:	Débora Romualdo Lacerda Kátia Anunciação Costa Ana Letícia Malheiros Silveira Débora Fernandes Rodrigues Albená Nunes Silva Josiana Lopes Sabino Vanessa Pinho Gustavo Batista de Menezes Danusa Dias Soares Mauro Martins Teixeira Adaliene Versiani Matos Ferreira
Abstract:	Inflammation induced by obesity contributes to insulin resistance and atherosclerosis. Indeed, high levels of proinflammatory cytokines trigger chronic low-grade inflammation and promote detrimental metabolic effects in the adipose tissue. On the other hand, inflammation seems to control fat pad expansion and to have important functions on lipolysis and glucose metabolism. Thus, it is possible that inflammation may also drive fat pad loss, as seen during long-fast periods. Herein, we have used fasting as a strategy to induce weight loss and evaluate the possible role of inflammation on adipose tissue remodeling. Male BALB-c mice were fed with chow diet (lean mice) or with high-carbohydrate refined diet (mildly obese mice) for 8 weeks. After that, animals were subjected to 24 h of fasting. There was a 63% reduction of adiposity in lean mice following fasting. Furthermore, the adipose tissue was enriched of immune cells and had a higher content of IL-6, TNF-alpha, IL-10, TGF-β and CXCL-1. Interestingly, mildly obese mice, subjected to the same 24-h fasting period, lost only 33% of their adiposity. Following fasting, these mice did not show any increment in leukocyte recruitment and cytokine levels, as did lean mice. Our findings indicate that inflammation participates in fat mass loss induced by fasting. Although the chronic low-grade inflammation seen in obesity is associated with metabolic diseases, a lower inflammatory response triggered by fasting in mildly obese mice impairs fat pad mobilization.
Subject:	Jejum Obesidade Inflamação Citocinas Citocinas Tecido adiposo Perda de peso
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	EEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA ENF - DEPARTAMENTO DE NUTRIÇÃO ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.jnutbio.2019.06.006
URI:	http://hdl.handle.net/1843/43998
Issue Date:	Oct-2019
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S0955286318304303#:~:text=Our%20findings%20indicate%20that%20inflammation,mice%20impairs%20fat%20pad%20mobilization.
metadata.dc.relation.ispartof:	Journal of Nutritional Biochemistry
Appears in Collections:	Artigo de Periódico

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.