Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44214
Type: Artigo de Periódico
Title: Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
Authors: Eliane Macedo Sobrinho Santos
Hércules Otacílio Santos
Ivoneth dos Santos Dias
Sergio Henrique Sousa Santos
Alfredo Maurício Batista de Paula
John David Feltenberger
André Luiz Sena Guimarães
Lucyana Conceição Farias
Abstract: Pathogenesis of odontogenic tumors is not well known. It is important to identify genetic deregulations and molecular alterations. This study aimed to investigate, through bioinformatic analysis, the possible genes involved in the pathogenesis of ameloblastoma (AM) and keratocystic odontogenic tumor (KCOT). Genes involved in the pathogenesis of AM and KCOT were identified in GeneCards. Gene list was expanded, and the gene interactions network was mapped using the STRING software. “Weighted number of links” (WNL) was calculated to identify “leader genes” (highest WNL). Genes were ranked by K-means method and Kruskal-Wallis test was used (P<0.001). Total interactions score (TIS) was also calculated using all interaction data generated by the STRING database, in order to achieve global connectivity for each gene. The topological and ontological analyses were performed using Cytoscape software and BinGO plugin. Literature review data was used to corroborate the bioinformatics data. CDK1 was identified as leader gene for AM. In KCOT group, results show PCNA and TP53. Both tumors exhibit a power law behavior. Our topological analysis suggested leader genes possibly important in the pathogenesis of AM and KCOT, by clustering coefficient calculated for both odontogenic tumors (0.028 for AM, zero for KCOT). The results obtained in the scatter diagram suggest an important relationship of these genes with the molecular processes involved in AM and KCOT. Ontological analysis for both AM and KCOT demonstrated different mechanisms. Bioinformatics analyzes were confirmed through literature review. These results may suggest the involvement of promising genes for a better understanding of the pathogenesis of AM and KCOT.
Subject: Carcinogênese
Tumores odontogênicos
Células - Proliferação
Bioinformática
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
URI: http://hdl.handle.net/1843/44214
Issue Date: 6-Dec-2016
metadata.dc.url.externa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353982/
metadata.dc.relation.ispartof: International Journal of Molecular and Cellular Medicine
Appears in Collections:Artigo de Periódico



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