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Type:	Artigo de Periódico
Title:	Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice
Authors:	Leandro Ceotto Freitas Lima Soraya Wilke Saliba João Marcus de Oliveira Andrade Maria Luísa Cunha Puebla Cassini-Vieira John David Feltenberger Lucíola da Silva Barcelos André Luiz Sena Guimarães Alfredo Mauricio Batista de Paula Antônio Carlos Pinheiro de Oliveira Sérgio Henrique Sousa Santos
Abstract:	Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities of glucose-induced obesity in an excitotoxic state induced by a quinolinic acid (QA) animal model. Mice were divided into two groups that received different diets for 8 weeks: one group received a regular diet, and the other group received a high-fat diet (HF) to induce MS. The animals were submitted to a stereotaxic surgery and subdivided into four groups: Standard (ST), Standard-QA (ST-QA), HF and HF-QA. The QA groups were given a 250 nL quinolinic acid injection in the right striatum and PBS was injected in the other groups. Obese mice presented with a weight gain of 40 % more than the ST group beyond acquiring an insulin resistance. QA induced motor impairment and neurodegeneration in both ST-QA and HF-QA, although no difference was observed between these groups. The HF-QA group showed a reduction in adiposity when compared with the groups that received PBS. Therefore, the HF-QA group demonstrated a commitment-dependent metabolic pathway. The results suggest that an obesogenic diet does not aggravate the neurodegeneration induced by QA. However, the excitotoxicity induced by QA promotes a sirtuin pathway impairment that contributes to metabolic changes.
Subject:	Degeneração (Patologia) Síndrome metabólica Obesidade
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1007/s12035-016-9927-x
URI:	http://hdl.handle.net/1843/44256
Issue Date:	16-May-2016
metadata.dc.url.externa:	https://link.springer.com/article/10.1007/s12035-016-9927-x
metadata.dc.relation.ispartof:	Molecular Neurobiology
Appears in Collections:	Artigo de Periódico

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