Obesity-related genes and oral cancer: a bioinformatics approach and systematic review

Eliane Macedo Sobrinho Santos; Talita Antunes Guimarães; Hércules Otacílio Santos; Sueli Nunes Fonseca; Talita Antunes Guimarães; Carlos Alberto de Carvalho Fraga; Kimberly Marie Jones; Alfredo Maurício Batista de Paula; Sergio Henrique Sousa Santos; André Luiz Sena Guimarães; Lucyana Conceição Farias

Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44301

Type:	Artigo de Periódico
Title:	Obesity-related genes and oral cancer: a bioinformatics approach and systematic review
Authors:	Eliane Macedo Sobrinho Santos Talita Antunes Guimarães Hércules Otacílio Santos Sueli Nunes Fonseca Talita Antunes Guimarães Carlos Alberto de Carvalho Fraga Kimberly Marie Jones Alfredo Maurício Batista de Paula Sergio Henrique Sousa Santos André Luiz Sena Guimarães Lucyana Conceição Farias
Abstract:	It is important to understand the biological processes linking obesity and cancer to identify new molecular targets for development of better therapeutic strategies. This study aims to synthesize knowledge regarding possible associations between obesity-related genes and oral cancer. We performed literature review about “oral cancer” and “obesity”. Gene databases and bioinformatics algorithms were used to in silico investigation of interactions networks between proteincoding genes, leader genes and molecular pathways that can possibly to link both pathological mechanisms. To this, GeneCards database, softwares STRING, Metaboanalyst and Cytoscape were employed. Genes were found to interact directly or indirectly with both obesity and oral cancer. Analyses of clustering revealed the TP53 gene as leader gene. Leptin was presented in group with the highest scores of relevance. Protein-protein interaction network linking obesity and oral cancer exhibits a power law behavior (correlation: 0.907; R2:0.851). Analysis of linear regression shows that genes related to obesity and oral cancer have higher diseaserelated connectivity than a global connectivity. Onthological analysis demonstrated different mechanisms associated to obesity and oral cancer, such as regulation of apoptosis and positive regulation of cellular process. We hypothesized that leptin is a molecule key in the link between obesity and oral cancer, by interactions with the p53 protein through CREBBP and EP300 proteins and HIF-1α, promoting angiogenesis. This study sought to organize relevant informations to further illuminate the role of genes that may be related to obesity and oral cancer. Angiogenesis genes can to be suggested as important factors to link both pathological processes.
Subject:	Obesidade Boca - Câncer Neovascularização Bioinformática Células - Proliferação Carcinoma de células escamosas
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	10.4172/2329-9533.1000124
URI:	http://hdl.handle.net/1843/44301
Issue Date:	1-May-2016
metadata.dc.url.externa:	https://www.scitechnol.com/peer-review/obesityrelated-genes-and-oral-cancer-a-bioinformatics-approach-and-systematicreview-K3Eo.php?article_id=4926
metadata.dc.relation.ispartof:	Journal of Applied Bioinformatics & Computational Biology
Appears in Collections:	Artigo de Periódico

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