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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44385
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dc.creatorRogério Gonçalves da Rochapt_BR
dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorEloá Mangabeira Santospt_BR
dc.creatorEmisael Stênio Batista Gomespt_BR
dc.creatorGuilherme Veloso Ramospt_BR
dc.creatorKarina Marini Aguiarpt_BR
dc.creatorBruno Rodrigues Gonçalvespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.date.accessioned2022-08-19T13:21:19Z-
dc.date.available2022-08-19T13:21:19Z-
dc.date.issued2019-01-
dc.citation.volume48pt_BR
dc.citation.issue1pt_BR
dc.citation.spage17pt_BR
dc.citation.epage23pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12786pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44385-
dc.description.resumoPurpose: leptin, an important hormone controlling energy homeostasis, has been linked to the pathogenesis of oral squamous cell carcinoma (OSCC). Evidence indicates that head and neck cancer patients undergoing radiotherapy show decreased leptin levels after radiotherapy treatment. Thus, we investigated, through phenotypic and molecular analyses, whether leptin can compromise the therapeutic effect of ionizing radiation and neoplastic behavior of OSCC cells. Methods: the human OSCC-derived cell lines SCC9 and SCC4 were treated with human recombinant leptin and exposed to 6 Gy of irradiation. We performed the in vitro assays of cell migration, death, proliferation, and colony-forming ability. The reactive oxygen species (ROS) levels and proteome analysis by mass spectrometry were also conducted. Results: leptin was able to increase cell proliferation, migration, and colony-forming ability, despite the suppressive effect induced by irradiation. Furthermore, the leptin promoted a significant reduction of ROS intracellular accumulation, and increased expression of the cancer-related proteins, as ACTC1, KRT6A, and EEF2 in irradiated OSCC cells. Conclusions: our findings suggest that leptin impairs responsivity of OSCC cells to the ionizing radiation, reducing the suppressive effects of irradiation on the neoplastic phenotype, and increasing protein expression critical to carcinogenesis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology and Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherRadiação ionizantept_BR
dc.subject.otherHomeostasept_BR
dc.subject.otherCélulas - Proliferaçãopt_BR
dc.subject.otherCarcinogênesept_BR
dc.titleLeptin impairs the therapeutic effect of ionizing radiation inoral squamous cell carcinoma cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12786pt_BR
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