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Type:	Artigo de Periódico
Title:	Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study
Authors:	Raquel Gusmão Soares Lucyana Conceição Farias Agna Soares da Silva Menezes Carla Silvana de Oliveira e Silva Angeliny Tamiarana Lima Tabosa Pablo Vinicyus Ferreira Chagas Laís Santiago Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula André Luiz Sena Guimarães
Abstract:	Oral squamous cell carcinoma (OSCC) is the most frequent oral malignant neoplasia. As consequence of OSCC treatment, oral mucositis (OM) is one of the most common adverse effects of OSCC treatment. Currently, there is no consensus for OM treatment. The purpose of the current study was to test the combination of red and infrared low-level laser therapy (LLLT) for OM treatment. Primary culture of human fibroblast was performed to identify LLLT dose. After laboratory tests, a two-arm parallel, single-blind, controlled study was conducted. The two arms were group 1, both 660- and 808-nm wavelengths (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2), and group 2, only 660-nm wavelength (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2). Both treatments were performed twice a week. Group 1 presented a reduction of mucositis grade in comparison to group 2. Group 1 also presented reduction of analgesics prescription. But no significant differences between groups 1 and 2 were observed according to the pain scale. In conclusion, the current study demonstrated that a combination of red and infrared at a higher dose (300 J/cm2) reduced both oral mucositis grade and analgesics prescription. The effects of the combination of RT and LLLT are unclear and need more studies.
Subject:	Boca - Câncer Lasers em medicina Fototerapia Carcinoma de células escamosas
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1007/s10103-018-2549-y
URI:	http://hdl.handle.net/1843/44435
Issue Date:	15-Jun-2018
metadata.dc.url.externa:	https://link.springer.com/article/10.1007/s10103-018-2549-y
metadata.dc.relation.ispartof:	Lasers in Medical Science
Appears in Collections:	Artigo de Periódico

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