Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44449
Type: Artigo de Periódico
Title: Celecoxib modulates renin-angiotensin system in the adipose tissue of obese mice
Authors: Jamille Fernandes Lula
Toni Ramos Alves de Souza
Keila Lopes Mendes
Alanna Fernandes Paraíso
Deborah de Farias Lelis
João Marcus Oliveira Andrade
Lucyana Conceição de Farias
Igor Viana Brandi
Alfredo Maurício Batista de Paula
Aline Hilzenderguer
André Luiz Sena Guimarães
Sergio Henrique Sousa Santos
Abstract: Background: the renin-angiotensin system (RAS) is a critical contributing factor to obesity and related diseases. Several studies have shown the relationship of obesity with cyclooxygenase-2. Objectives: based on these facts, we aimed to investigate the celecoxib oral administration (a selective anti-inflammatory inhibitor of cyclooxygenase-2 (ICOX-2)) effects, in mice fed a high-fat diet by assessing the renin-angiotensin system and inflammatory markers expression. Methods: FVB/N male mice were divided into 3 groups and fed with experimental diets, standard, high-fat diet and high-fat diet plus ICOX-2 at a dose of 100mg/kg/body weight. Body weight, food intake, blood parameters and RAS/inflammatory markers expression were assessed. Results: the main findings showed that diet-induced obese mice treated with COX-2 inhibitor showed significantly improved glucose and insulin homeostasis, presented decreased body weight gain and the biochemical analyses revealed reduced triglyceride levels and higher serum HDL-c levels as compared to HFD and ST. These results were accompanied by a downregulation of AGT, ACE, TNF-α and IL-6 expression in the group receiving treatment. Conclusion: taken together, these results indicate that ICOX-2 may exhibit therapeutic potential for obesity via the renin-angiotensin system and inflammation.
Subject: Obesidade
Sistema renina-angiotensina
Analgésicos
Agentes antiinflamatórios não esteróides
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
metadata.dc.identifier.doi: 10.2174/1573408014666180705145324
URI: http://hdl.handle.net/1843/44449
Issue Date: 2018
metadata.dc.url.externa: http://www.eurekaselect.com/article/91529
metadata.dc.relation.ispartof: Current Enzyme Inhibition
Appears in Collections:Artigo de Periódico

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