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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44508
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dc.creatorLeônidas das Graças Mendes Júniorpt_BR
dc.creatorLeandro Ceotto Freitas Limapt_BR
dc.creatorJanaína Ribeiro Oliveirapt_BR
dc.creatorMarcos de Abreu Melopt_BR
dc.creatorJohn David Feltenbergerpt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorBruna Mara Aparecida Carvalhopt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorCarlos Eduardo Mendes D'Angelispt_BR
dc.creatorMaria José Campagnole Santospt_BR
dc.creatorRobson Augusto Souza Santospt_BR
dc.creatorValdir Andrade Bragapt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-24T13:33:17Z-
dc.date.available2022-08-24T13:33:17Z-
dc.date.issued2018-09-15-
dc.citation.volume209pt_BR
dc.citation.spage341pt_BR
dc.citation.epage348pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2018.08.034pt_BR
dc.identifier.issn0024-3205pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44508-
dc.description.resumoDiabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144.95 ± 16.13 vs 92.90 ± 18.95 mm Hg), low glucose tolerance (AUC = 1049.01 ± 74.79 vs 710.50 ± 52.57 a.u.), decreased insulin sensitivity (AUC = 429.83 ± 35.22 vs 313.67 ± 19.55 a.u.) and increased adiposity (epididymal fat weight 0.96 ± 0.10 vs 0.59 ± 0.06 OW/BW × 102), aspects present in metabolic syndrome. Cardiac evaluation showed diastolic dysfunction (E/A ratio = 1.20 vs 1.90 u.a.) and cardiomyocyte hypertrophy (cardiomyocyte area = 502.82 ± 31.46 vs 385.58 ± 22.11 μm2). Lastly, vascular reactivity was impaired with higher contractile response (136.10 ± 3.49 vs 120.37 ± 5.43%) and lower response to endothelium-dependent vasorelaxation (74.01 ± 4.35 vs 104.84 ± 3.57%). In addition, the diet was able to induce an inward coronary remodeling (vascular total area: SCNS 6185 ± 800.6 vs HFHS 4085 ± 213.7 μm2). Therefore, we conclude that HFHS short-term treatment was able to induce metabolic syndrome-like state, cardiomyopathy and vascular injury working as an important tool to study cardiometabolic diseases.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofLife Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherMiocárdio - Doençaspt_BR
dc.subject.otherDiabetespt_BR
dc.titleThe usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S002432051830479X?via%3Dihub#!pt_BR
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