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Tipo:	Artigo de Periódico
Título:	Genetic variation in the promoter region of the TNF rs1800629 gene is not associated with adiposity index, but AA genotype is more likely to have low cellular membrane integrity
Autor(es):	Rosângela Ramos Veloso Silva Marise Fagundes Silveira Geórgia das Graças Pena Tatiana Carvalho Reis Martins Ugo Borges Pinheiro Renato Sobral Monteiro Júnior Sérgio Henrique Sousa Santos Alfredo Maurício Batista de Paula João Felício Rodrigues Neto André Luiz Sena Guimarães
Resumo:	Background: the complex pathophysiology of obesity includes low-grade chronic inflammation of white adipose tissue, an increase in plasma levels of pro-inflammatory cytokines as well as genetic factors, which have all emerged as important risk factors. Objective: evaluate the association between the TNFα-308G/A variant and sociodemographic, clinical and behavioral variables in an urban population using overall and central obesity as the measured outcome. Methods: a cross-sectional population-based study was conducted. Anthropometric measures and genotyping were assessed in 808 individuals. The associations were tested using the hierarchical theoretical model and multiple logistic regressions. Results: thirty-one percent of subjects were overweight while 19.4% were obese. No association was observed between genotype frequencies of TNFα-308G/A and either obesity or other variables of adiposity, including waist circumference, waist to height ratio, conicity index, and fat mass. However, age, gender, physical inactivity, and other comorbidities were associated with measures of excess adiposity in the hierarchical model. The phase angle of AA genotype was lower than GA and GG genotypes (p < 0.05). Conclusion: the rs1800629 SNP of the TNFA gene was not associated with the adiposity indicators evaluated in this based population study. However, AA genotype is more likely to have low cellular membrane integrity.
Assunto:	Obesidade Polimorfismo (Genética) Fator de necrose de tumor Antropometria Tecido adiposo
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1016/j.mgene.2017.05.005
URI:	http://hdl.handle.net/1843/44525
Data do documento:	Set-2017
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2214540017300373
metadata.dc.relation.ispartof:	Meta Gene
Aparece nas coleções:	Artigo de Periódico

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