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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44525
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dc.creatorRosângela Ramos Veloso Silvapt_BR
dc.creatorMarise Fagundes Silveirapt_BR
dc.creatorGeórgia das Graças Penapt_BR
dc.creatorTatiana Carvalho Reis Martinspt_BR
dc.creatorUgo Borges Pinheiropt_BR
dc.creatorRenato Sobral Monteiro Júniorpt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorJoão Felício Rodrigues Netopt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2022-08-24T15:06:31Z-
dc.date.available2022-08-24T15:06:31Z-
dc.date.issued2017-09-
dc.citation.volume13pt_BR
dc.citation.spage85pt_BR
dc.citation.epage91pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2017.05.005pt_BR
dc.identifier.issn2214-5400pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44525-
dc.description.resumoBackground: the complex pathophysiology of obesity includes low-grade chronic inflammation of white adipose tissue, an increase in plasma levels of pro-inflammatory cytokines as well as genetic factors, which have all emerged as important risk factors. Objective: evaluate the association between the TNFα-308G/A variant and sociodemographic, clinical and behavioral variables in an urban population using overall and central obesity as the measured outcome. Methods: a cross-sectional population-based study was conducted. Anthropometric measures and genotyping were assessed in 808 individuals. The associations were tested using the hierarchical theoretical model and multiple logistic regressions. Results: thirty-one percent of subjects were overweight while 19.4% were obese. No association was observed between genotype frequencies of TNFα-308G/A and either obesity or other variables of adiposity, including waist circumference, waist to height ratio, conicity index, and fat mass. However, age, gender, physical inactivity, and other comorbidities were associated with measures of excess adiposity in the hierarchical model. The phase angle of AA genotype was lower than GA and GG genotypes (p < 0.05). Conclusion: the rs1800629 SNP of the TNFA gene was not associated with the adiposity indicators evaluated in this based population study. However, AA genotype is more likely to have low cellular membrane integrity.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMeta Genept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherPolimorfismo (Genética)pt_BR
dc.subject.otherFator de necrose de tumorpt_BR
dc.subject.otherAntropometriapt_BR
dc.subject.otherTecido adiposopt_BR
dc.titleGenetic variation in the promoter region of the TNF rs1800629 gene is not associated with adiposity index, but AA genotype is more likely to have low cellular membrane integritypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2214540017300373pt_BR
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