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http://hdl.handle.net/1843/44579| Type: | Artigo de Periódico |
| Title: | High levels of ANXA2 are characteristic of malignant salivary gland tumors |
| Authors: | Cláudio Marcelo Cardoso Sabrina Ferreira de Jesus Marcela Gonçalves de Souza Lorena dos Reis Pereira Queiroz Eloa Mangabeira Santos Erivelton Pereira dos Santos Luís Paulo Oliveira Cristiane Karine Cordeiro Santos Sérgio Henrique Sousa Santos Alfredo Maurício Batista de Paula Lucyana Conceição Farias André Luiz Sena Guimarães |
| Abstract: | Objective: malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT. Methods: for screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT-associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls. Results: 16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA. Conclusion: in conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS. |
| Subject: | Boca - Câncer Metástase Tumores Glândulas salivares - Doenças |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jop.12932 |
| URI: | http://hdl.handle.net/1843/44579 |
| Issue Date: | 20-Jul-2019 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.12932 |
| metadata.dc.relation.ispartof: | Journal of Oral Pathology and Medicine |
| Appears in Collections: | Artigo de Periódico |
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