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http://hdl.handle.net/1843/44664| Type: | Artigo de Periódico |
| Title: | Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice |
| Authors: | Gabriela Cavazza Cerri Leandro Ceotto Freitas Lima Deborah de Farias Lelis Lucíola da Silva Barcelos John David Feltenberger Samuel Vidal Mussi Renato Sobral Monteiro Júnior Robson Augusto Souza dos Santos Lucas Antônio Miranda Ferreira Sergio Henrique Sousa Santos |
| Abstract: | Sclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects. Aims: the present study aimed to evaluate the effects of Sclareol in different formulations (solid lipid nanoparticle and free) on the metabolic profile of obese mice. Main methods: swiss male mice were randomly divided into two groups: standard diet (STD) and high-fat diet (HFD). After obesity induction, each group was divided into three treatment groups: free Sclareol (Sc), Sclareol-loaded lipid nanoparticle (L-Sc) and blank lipid nanoparticle (L). Treatments were performed every day during 30 days. Key findings: L-Sc improves obese mice metabolic profile by decreasing adiposity, ameliorating insulin sensitivity, glucose tolerance and increasing the HDL plasma levels. In addition, L-Sc decreased the expression of NF-KB, MCP-1 and SERBP-1. Significance: the use of sclareol together with lipid nanocarriers may be promising for the treatment of metabolic disorders by reducing adipose tissue. |
| Subject: | Obesidade Diterpenos Essências e óleos essenciais Tecido adiposo Nanopartículas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.lfs.2018.12.063 |
| URI: | http://hdl.handle.net/1843/44664 |
| Issue Date: | Feb-2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0024320518308609 |
| metadata.dc.relation.ispartof: | Life Sciences |
| Appears in Collections: | Artigo de Periódico |
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