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http://hdl.handle.net/1843/44695| Type: | Artigo de Periódico |
| Title: | Angiotensin-(1-7), adipokines and inflammation |
| Authors: | Deborah de Farias Lelis Daniela Fernanda de Freitas Amanda Souto Machado Thaísa Soares Crespo Sergio Henrique Sousa Santos |
| Abstract: | Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses angiotensin-(1–7), which is now recognized as the main peptide on counteracting Ang II effects. New studies have shown that increased activation of ACE2/Ang-(1–7)/MasR arm can revert and prevent local and systemic dysfunctions improving lipid profile and insulin resistance by modulating insulin actions, and reducing inflammation. In this context, the present review shows the interaction and relevance of Ang-(1–7) effects on regulating adipokines, and as one adipokine itself, modulating body homeostasis, with emphasis on its anti-inflammatory properties, especially in the context of metabolic disorders with focus on obesity and type 2 diabetes mellitus pandemic. |
| Subject: | Sistema renina-angiotensina Enzima conversora da angiotensina Tecido adiposo Inflamação Homeostase Obesidade Diabetes |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.metabol.2019.03.006 |
| URI: | http://hdl.handle.net/1843/44695 |
| Issue Date: | Jun-2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0026049519300629?via%3Dihub |
| metadata.dc.relation.ispartof: | Metabolism |
| Appears in Collections: | Artigo de Periódico |
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