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Type:	Artigo de Periódico
Title:	Oral probiotic Bifidobacterium longum supplementation improves metabolic parameters and alters the expression of the renin-angiotensin system in obese mice liver
Authors:	Amanda Souto Machado Janaína Ribeiro Oliveira Deborah de Farias Lelis Alfredo Maurício Batista de Paula André Luiz Sena Guimarães João Marcus Oliveira Andrade Igor Viana Brandi Sérgio Henrique Sousa Santos
Abstract:	Background: obesity and non-alcoholic fatty liver disease (NAFLD) have been increasing at an alarming rate worldwide. Bifidobacterium longum (BL), a common member of the human gut microbiota, has important health benefits through several mechanisms. Objectives: we evaluated the BL supplementation effects on body metabolism and renin-angiotensin components hepatic expression in mice fed a high-fat diet. Methods: thirty-two male mice were divided into four groups: standard diet + placebo (ST), standard diet + Bifidobacterium longum (ST + BL), high-fat diet + placebo (HFD) and high-fat diet + Bifidobacterium longum (HFD + BL). Following the obesity induction period, the ST + BL and HFD + BL groups were supplemented with Bifidobacterium longum for 4 weeks. Then, body, biochemical, histological and molecular parameters were evaluated. Results: HFD + BL mice had a significant decrease in adipose tissue mass and blood glucose levels, as well as a significant reduction in blood glucose during an intraperitoneal glucose tolerance test. The treatment also resulted in reduced levels of total cholesterol and hepatic fat accumulation. Moreover, we observed an increase in angiotensin converting enzyme 2 (ACE2) and Mas receptor (MASR) expression levels in BL-treated obese mice. Conclusions: these data demonstrate that BL may have the potential to prevent obesity and NAFLD by modulating the mRNA expression of renin-angiotensin system components.
Subject:	Sistema renina-angiotensina Obesidade Fígado - Doenças Tecido adiposo
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1177/1099800420942942
URI:	http://hdl.handle.net/1843/44950
Issue Date:	23-Jul-2020
metadata.dc.url.externa:	https://journals.sagepub.com/doi/full/10.1177/1099800420942942
metadata.dc.relation.ispartof:	Biological Research for Nursing
Appears in Collections:	Artigo de Periódico

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