Use este identificador para citar o ir al link de este elemento:
http://hdl.handle.net/1843/45005| Tipo: | Artigo de Periódico |
| Título: | Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model |
| Autor(es): | Victor Hugo Dantas Guimarães Deborah de Farias Lelis Luís Paulo Oliveira Luciana Mendes Araújo Borém Felipe Alberto Dantas Guimarães Lucyana Conceição Farias Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sérgio Henrique Sousa Santos |
| Resumen: | Background: diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases. Objective: the present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice. Methods: swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed. Results: the main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity. Conclusions: high-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results. |
| Asunto: | Obesidade Síndrome metabólica Stress oxidativo Hiperglicemia Esteatose hepática Açúcar no organismo |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1080/13813455.2020.1835986 |
| URI: | http://hdl.handle.net/1843/45005 |
| Fecha del documento: | 11-nov-2020 |
| metadata.dc.url.externa: | https://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1835986?journalCode=iarp20 |
| metadata.dc.relation.ispartof: | Archives of Physiology and Biochemistry |
| Aparece en las colecciones: | Artigo de Periódico |
archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.