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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45005
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dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorLuciana Mendes Araújo Borémpt_BR
dc.creatorFelipe Alberto Dantas Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2022-09-08T15:30:45Z-
dc.date.available2022-09-08T15:30:45Z-
dc.date.issued2020-11-11-
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1080/13813455.2020.1835986pt_BR
dc.identifier.issn1744-4160pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45005-
dc.description.resumoBackground: diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases. Objective: the present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice. Methods: swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed. Results: the main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity. Conclusions: high-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Physiology and Biochemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherStress oxidativopt_BR
dc.subject.otherHiperglicemiapt_BR
dc.subject.otherEsteatose hepáticapt_BR
dc.subject.otherAçúcar no organismopt_BR
dc.titleComparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1835986?journalCode=iarp20pt_BR
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