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http://hdl.handle.net/1843/45416| Type: | Artigo de Periódico |
| Title: | Chemical, microscopic, and microbiological analysis of a functionalizedpoly-ether-ether-ketone-embedding antibiofilm compounds |
| Authors: | Juan Felipe Dumes Montero Luiz Cláudio de Almeida Barbosa Ulisses Alves Pereira Guilherme Mariz de Oliveira Barra Marcio Celso Fredel Cesar Augusto Magalhães Benfatti Ricardo de Souza Magini Andréa de Lima Pimenta Júlio César Matias de Souza |
| Abstract: | Poly-ether-ether-ketone (PEEK) is currently introduced as an alternative material for orthopedic implants due to its biocompatibility and low elastic modulus compared to titanium. Also, a sulphonation treatment can functionalize PEEK to embed therapeutical substances. The objective of this work was to functionalize a PEEK film to incorporate novel lactam-based antibiofilms compounds. PEEK samples were functionalized by sulphuric acid treatment and then dissolved in dimethylsulfoxide, where lactams were added to be incorporated into the polymer. A dip-coating technique was used to synthesize a thin film on a glass-based substrate. The degree of sulfonation (DS) and the incorporation of lactams into sulphonated PEEK (sPEEK) were analyzed by Fourier transform infrared spectroscopy, nuclear magnetic resonance, thermogravimetric analysis (TGA), and scanning electron microscopy. A DS of 65% was obtained and TGA curves confirmed the presence of SO3H and lactams in the sPEEK structure. The growth of Streptococcus mutans biofilm decreased on sPEEK surface containing lactams when compared to sPEEK free of lactams. That indicated the antibiofilm activity of those compounds was maintained after incorporation into sPEEK. Planktonic growth analysis showed no long distant effects of sPEEK containing lactams, indicating that no systemic effects should be expected upon clinical uses of medical devices produced with lactam-treated sPEEK. Results revealed that inclusion of lactams into sPEEK represents a good alternative for the production of biomaterials resistant to bacterial accumulation. |
| Subject: | Streptococcus mutans Biofilme Implantes ortopédicos Espectroscopia de infravermelho Lactamas Materiais biomédicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1002/jbm.a.35842 |
| URI: | http://hdl.handle.net/1843/45416 |
| Issue Date: | 26-Jul-2016 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.35842 |
| metadata.dc.relation.ispartof: | Journal of Biomedical Materials Research Part A |
| Appears in Collections: | Artigo de Periódico |
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